Welcome to Fiveprime

Nathan Siemers


Biology   Chemistry   Informatics   Music   Photography


CV I am a director of research and development at a pharmaceutical company. I'm cross-trained in Chemistry, Biology, Data Science, and Informatics. I've led research/development groups of 1-25 people over my career. My training and experience has made me adept at integrating information and synthesizing hypotheses and conclusions across diverse domains of science and medicine.

"Faux Flow" viewer for single cell Melanoma RNA-seq data I've been working on flow-cytometry-like viewers for cancer single-celll rna-seq data. Here's a viewer for the Tirosh et al. Melanoma paper (fantastic paper).

"Faux Flow" viewer for single cell liver cancer RNA-seq data Here's a viewer for a recent hepatocellular carcinoma T cell data set from Zheng et al.

"Faux Flow" viewer for single cell, blood derived, monocytes and dendritic cells Alexandra-ChloƩ Villani et al.

TCGA (cancer) and GTEX (normal human tissue) data browser Many thanks to the UCSC Xena team and the TOIL project to make unified data available!

Flickr Hive Mind: I am the author of Flickr Hive Mind, a photography database mining tool. I wrote Flickr Hive Mind over a decade ago as an experiment in the use of the modern web, web APIs, and folksonomies. I've continued to support and enhance the tool, which is now used by millions of people a month to explore Flickr. Maintaining an internet web site that performs a somewhat complex set of operations while getting hit 50 times a second is also a good way to keep my informatics skills in shape.

Photography Photography has one of my endeavors over the past decade. I wasn't a natural. I struggled. I have improved. The link takes you to my Flickr photo stream, as visualized by Flickr Hive Mind.

Music I'm a cellist who has performed in a number of local chamber groups as well as the Westminster Community Orchestra (Westminster Conservatory, Princeton, New Jersey, USA). The link takes you to 1990s (now ancient) recordings of the Polter String Quartet, which perfomed around Ithaca, New York during my time at Cornell University.